Dr. Chang Liu
Research Scientist,
SCIEX
We describe an innovative Acoustic Ejection Mass Spectrometry (AEMS) platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray ionization (ESI) MS that creates a transformative system enabling high-speed sampling and label-free analysis. The ADE technology delivers nanoliter droplets in a touchless manner with high speed, precision and accuracy; subsequent sample dilution within the OPI, in concert with the capabilities of modern ESI-MS, eliminates the laborious sample preparation and method development required in current approaches. This AEMS platform is applied to a variety of workflows, including high-throughput (HT) pharmacology screening, label-free in situ enzyme kinetics, in vitro and in vivo adsorption, distribution, metabolism, elimination, pharmacokinetic (PK) and biomarker analysis, compound QC, HT parallel medicinal chemistry, and synthetic biology. The system principles and representative applications of AEMS technology will be discussed in this talk.
 Dr. Chang Liu earned his B.Sc. in Chemistry from Peking University, China, and his Ph.D. in Analytical Chemistry from the University of British Columbia, Canada. Chang joined SCIEX in 2013 as a scientist where he has been working on the front-end sample preparation and sample introduction technologies, and their applications in high-throughput drug discovery. Dr. Liu has published more than 30 papers and was the organizer of the High-throughput MS session for Pittcon. He was the recipient of Danaher Excellence in Innovation Award, CSC Ryan-Harris Award, and ACS Analytical Chemistry Graduate Fellowship.
Hosted by Professor Krishna Mahadevan